SPECTROFLUOROMETRIC DETERMINATION OF NALIDIXIC-ACID BASED ON HOST-GUEST COMPLEXATION WITH GAMMA-CYCLODEXTRIN

被引：46

作者：

DURANMERAS, I ^{[1
]}

DELAPENA, AM ^{[1
]}

SALINAS, F ^{[1
]}

CACERES, IR ^{[1
]}

机构：

[1] UNIV EXTREMADURA,DEPT ANALYT CHEM,E-06071 BADAJOZ,SPAIN

来源：

ANALYST | 1994年 / 119卷 / 06期

关键词：

NALIDIXIC ACID DETERMINATION; GAMMA-CYCLODEXTRIN; SPECTROFLUOROMETRY; HOST-GUEST COMPLEXATION;

D O I：

10.1039/an9941901215

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The characteristics of host-guest complexation between gamma-cyclodextrin and nalidixic acid were investigated by fluorescence spectrometry. A 1:1 stoichiometry of the complex was established and an association constant of 292 l mol(-1) was calculated by using the changes in the fluorescence of nalidixic acid that occurred when it was included in the hydrophobic cyclodextrin cavity. A spectrofluorimetric method for the determination of nalidixic acid was developed, with a range of application between 0.1 and 2 mu g ml(-1). The method was applied satisfactorily to the determination of nalidixic acid in a pharmaceutical preparation and in urine.

引用

页码：1215 / 1219

页数：5

共 26 条

[1]

[Anonymous], 1978, SPECTROCHIM ACTA B, V33, P242

[2]

[Anonymous], 1980, ANAL CHEM, V52, P2242

[3]

[Anonymous], 1996, COMPREHENSIVE SUPERM

[4] SURFACTANT AND CYCLODEXTRIN FLUORESCENCE ENHANCEMENT OF DANSYLAMINO ACIDS AND OF THIOL-AMMONIUM 7-FLUOROBENZO-2-OXA-1,3-DIAZOLE-4-SULFONATE DERIVATIVES [J].

BAEYENS, W ;

LIN, B ;

CORBISIER, V .

ANALYST, 1990, 115 (04) :359-363

[5] ENHANCED FLUORESCENCE FROM ORTHO-PHTHALALDEHYDE AND FLUORESCAMINE FLUOROPHORES USING TRITON AND BETA-CYCLODEXTRIN [J].

BAEYENS, WRG ;

LING, BL ;

CORBISIER, V ;

RAEMDONCK, A .

ANALYTICA CHIMICA ACTA, 1990, 234 (01) :187-192

[6] FLUORESCENCE STUDIES ON SOME HYDROXYPYRIDINES INCLUDING COMPOUNDS OF VITAMIN B6 GROUP [J].

BRIDGES, JW ;

DAVIES, DS ;

WILLIAMS, RT .

BIOCHEMICAL JOURNAL, 1966, 98 (02) :451-&

[7]

BROWNING RS, 1970, J ASSOC OFF ANA CHEM, V53, P464

[8]

DASILVA MJJ, 1966, REV PORT FARM, V15, P290

[9]

Dondi G, 1966, Boll Chim Farm, V105, P491

[10] DRUG-THERAPY REVIEWS - NALIDIXIC-ACID [J].

GLECKMAN, R ;

ALVAREZ, S ;

JOUBERT, DW ;

MATTHEWS, SJ .

AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1979, 36 (08) :1071-1076

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