At the heart of the chromosome: SMC proteins in action

被引:426
作者
Hirano, T [1 ]
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrm1909
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Structural maintenance of chromosomes (SMC) proteins are ubiquitous in organisms from bacteria to humans, and function as core components of the condensin and cohesin complexes in eukaryotes. SMC proteins adopt a V-shaped structure with two long arms, each of which has an ATP-binding head domain at the distal end. It is important to understand how these uniquely designed protein machines interact with DNA strands and how such interactions are modulated by the ATP-binding and -hydrolysis cycle. An emerging idea is that SMC proteins use a diverse array of intramolecular and intermolecular protein-protein interactions to actively fold, tether and manipulate DNA strands.
引用
收藏
页码:311 / 322
页数:12
相关论文
共 82 条
[21]   C-elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis [J].
Hagstrom, KA ;
Holmes, VF ;
Cozzarelli, NR ;
Meyer, BJ .
GENES & DEVELOPMENT, 2002, 16 (06) :729-742
[22]   Opening closed arms: Long-distance activation of SMC ATPase by hinge-DNA interactions [J].
Hirano, M ;
Hirano, T .
MOLECULAR CELL, 2006, 21 (02) :175-186
[23]   Positive and negative regulation of SMC-DNA interactions by ATP and accessory proteins [J].
Hirano, M ;
Hirano, T .
EMBO JOURNAL, 2004, 23 (13) :2664-2673
[24]   Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA [J].
Hirano, M ;
Hirano, T .
EMBO JOURNAL, 2002, 21 (21) :5733-5744
[25]   Bimodal activation of SMC ATPase by intra- and inter-molecular interactions [J].
Hirano, M ;
Anderson, DE ;
Erickson, HP ;
Hirano, T .
EMBO JOURNAL, 2001, 20 (12) :3238-3250
[26]   ATP-dependent aggregation of single-stranded DNA by a bacterial SMC homodimer [J].
Hirano, M ;
Hirano, T .
EMBO JOURNAL, 1998, 17 (23) :7139-7148
[27]   Condensins: Organizing and segregating the genome [J].
Hirano, T .
CURRENT BIOLOGY, 2005, 15 (07) :R265-R275
[28]   SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? [J].
Hirano, T .
GENES & DEVELOPMENT, 1999, 13 (01) :11-19
[29]   Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily [J].
Hopfner, KP ;
Karcher, A ;
Shin, DS ;
Craig, L ;
Arthur, LM ;
Carney, JP ;
Tainer, JA .
CELL, 2000, 101 (07) :789-800
[30]   Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures [J].
Hopfner, KP ;
Tainer, JA .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2003, 13 (02) :249-255