STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis

被引:34
作者
Betz, Aurel [1 ]
Ryoo, Hyung Don [3 ]
Steller, Hermann [2 ]
Darnell, James E., Jr. [1 ]
机构
[1] Rockefeller Univ, Mol Cell Biol Lab, New York, NY 10065 USA
[2] Rockefeller Univ, Howard Hughes Med Inst, Lab Apoptosis & Canc Biol, New York, NY 10065 USA
[3] NYU, Med Ctr, Dept Cell Biol, New York, NY 10016 USA
基金
美国国家卫生研究院;
关键词
Jak STAT; stress; cancer; survival;
D O I
10.1073/pnas.0806291105
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The proapoptotic factors Reaper, Hid, Grim, and Sickle regulate apoptosis in Drosophila by inhibiting the antiapoptotic factor DIAP1 (Drosophila inhibitor of apoptosis 1). Heat, UV light, x-rays, and developmental signals can all increase the proapoptotic factors, but the control of transcription of the diap1 gene is unclear. We show that in imaginal discs the single Drosophila STAT protein (STAT92E) when activated can directly increase DIAN through binding to STAT DNA-binding sites in the diap1 promoter. The STAT92E contribution to DIAN production is required for cell survival after x-irradiation but not under unstressed conditions. Because DIAP1 prevents apoptosis after a variety of stresses, STAT92E may have a role in regulating stress responses in general.
引用
收藏
页码:13805 / 13810
页数:6
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