Stability and Utility of Pyridyl Disulfide Functionality in RAFT and Conventional Radical Polymerizations

被引：213

作者：

Boyer, Cyrille ^{[2
]}

Liu, Jingquan ^{[2
]}

Wong, Lingjiun ^{[2
]}

Tippett, Michael ^{[2
]}

Bulmus, Volga ^{[1
]}

Davis, Thomas P. ^{[2
]}

机构：

[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Sch Chem Sci & Engn, CAMD, Sydney, NSW 2052, Australia

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2008年 / 46卷 / 21期

基金：

澳大利亚研究理事会;

关键词：

bioconjugation; chemical modification; conjugated polymers; functionalization of polymers; radical polymerization; reversible addition fragmentation chain transfer (RAFT);

D O I：

10.1002/pola.23028

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Two RAFT agents, suitable for inducing living radical polymerization in water, have been synthesized. Both RAFT agents were shown to be effective over the temperature range 25-70 degrees C. One RAFT agent was functionalized. with a pyridyl disulfide group. RAFT efficacy was demonstrated for the polymerizations of N-isopropyl acrylamide (NIPAAM) and poly(ethylene oxide)-acrylate (PEG-A) in both water and acetonitrile. The kinetic data indicates that the pyridyl disulfide functionality is largely benign in free radical polymerizations, remaining intact for subsequent reaction with thiol groups. This result was confirmed by studying conventional radical polymerizations in the presence of hydroxyethyl pyridyl disulfide. The utility of the pyridyl disulfide functionality at the terminus of the polymers was demonstrated by synthesizing polymer-BSA conjugates. (C) 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7207-7224, 2008

引用

页码：7207 / 7224

页数：18