Inhibition of hepatitis B virus replication by interferon requires proteasome activity

被引：73

作者：

Robek, MD ^{[1
]}

Wieland, SF ^{[1
]}

Chisari, FV ^{[1
]}

机构：

[1] Scripps Res Inst, Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 07期

关键词：

D O I：

10.1128/JVI.76.7.3570-3574.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Hepatitis B virus (HBV) replication is inhibited in a noncytopathic manner by alpha/beta interferon (IFN-alpha/beta) and IFN-gamma. We demonstrate here that inhibitors of cellular proteasome activity can block this antiviral effect. These results suggest that a critical component of the IFN-induced antiviral response may be the proteasome-dependent degradation of viral or cellular proteins that are required for HBV replication.

引用

页码：3570 / 3574

页数：5

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