Dendrimers and DNA: Combinations of two special topologies for nanomaterials and biology

被引：114

作者：

Caminade, Anne-Marie ^{[1
]}

Turrin, Cedric-Olivier ^{[1
]}

Majoral, Jean-Pierre ^{[1
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 25期

关键词：

biology; dendrimers; DNA; nanomaterials; self-assembly;

D O I：

10.1002/chem.200800584

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Interactions between two precisely defined three-dimensional architectures (DNA and dendrimers) are described. Highly synergetic effects occur, as illustrated in two cases: dendrimers can be used as three-dimensional linkers for oligonucleotides, affording highly sensitive microarrays (biochips), and positively charged dendrimers strongly interact with DNA, allowing penetration inside cells (genetic transfection).

引用

页码：7422 / 7432

页数：11

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