Mesenchymal stem cells in health and disease

被引：2823

作者：

Uccelli, Antonio ^{[1
,2
,3
]}

Moretta, Lorenzo ^{[2
,4
,5
]}

Pistoia, Vito ^{[4
]}

机构：

[1] Univ Genoa, Dept Neurosci Ophthalmol & Genet, I-16126 Genoa, Italy

[2] Univ Genoa, Ctr Excellence Biomed Res, I-16126 Genoa, Italy

[3] ABC, Genoa, Italy

[4] IRCSS Giannina Gaslini, Genoa, Italy

[5] Univ Genoa, Dept Expt Med DIMES, I-16126 Genoa, Italy

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 09期

关键词：

D O I：

10.1038/nri2395

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues. They can differentiate into cells of the mesodermal lineage, such as adipocytes, osteocytes and chondrocytes, as well as cells of other embryonic lineages. MSCs can interact with cells of both the innate and adaptive immune systems, leading to the modulation of several effector functions. After in vivo administration, MSCs induce peripheral tolerance and migrate to injured tissues, where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells. This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches.

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页码：726 / 736

页数：11

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