Pd-Catalyzed Thiocarbonylation with Stoichiometric Carbon Monoxide: Scope and Applications

被引：119

作者：

Burhardt, Mia N. ^{[1
]}

Taaning, Rolf H. ^{[1
]}

Skrydstrup, Troels ^{[1
]}

机构：

[1] Aarhus Univ, Interdisciplinary Nanosci Ctr, Dept Chem, Ctr Insoluble Prot Struct inSPIN, DK-8000 Aarhus C, Denmark

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

HIGHLY REGIOSELECTIVE THIOCARBONYLATION; FORMING REDUCTIVE ELIMINATION; CARBONYLATIVE HECK REACTION; ARYL HALIDES; PALLADIUM COMPLEXES; EFFICIENT SYNTHESIS; 1ST EXAMPLES; LU AA21004; EX-SITU; THIOLS;

D O I：

10.1021/ol400138m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general protocol for the Pd-catalyzed thiocarbonylation of aryl iodides with stoichiometric carbon monoxide has been established employing a catalytic system composed of Pd(OAc)(2) and DPEphos with low catalyst loading (1 mol %). Both electron-rich and -deficient aryl iodides proved effective for these couplings with aryl and alkyl thiols. The choice of the metal ligands and the solvent system was crucial for the efficiency and chemoselectivity of these transformations.

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页码：948 / 951

页数：4

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