共 41 条
Superantigens augment antigen-specific Th1 responses by inducing IL-12 production in macrophages
被引:28
作者:
Bright, JJ
[1
]
Xin, ZC
[1
]
Sriram, S
[1
]
机构:
[1] Vanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USA
关键词:
T lymphocyte;
cytokine;
staphylococcal enterotoxin B;
D O I:
10.1002/jlb.65.5.665
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Superantigens (SAg) are microbial proteins that mediate antigen-presenting cell (APC)-T cell interaction by cross-linking MHC class II molecules with subsets of TcRV beta, SAgs are implicated in the pathogenesis of several infectious, inflammatory, and autoimmune diseases. In this study, rue examined the influence of SEE on interleukin-12 (IL-12) production and the activation of antigen-specific Till responses. Addition of SEE augmented the antigen-induced proliferation of HS-17, a murine MBPp91-103 peptide-specific TcRV beta 6(+) CD4(+) Th1 clone. SEE augments HS-17 T cell proliferation through its interaction with IA(s) molecules on macrophages, hot not with the TcRV beta 6 on HS-17 cells. On binding to IAS, SEE induces IL-12 production in macrophages, which in turn augments antigen-induced proliferation of HS-17 T cells. Treatment with anti-IA(s) mAb 10-3.6 inhibited the antigen- and SEB-induced IL-12 production and T cell proliferation. These results suggest that SAgs augment antigen-specific T cell responses by inducing IL-12 production in macrophages.
引用
收藏
页码:665 / 670
页数:6
相关论文