Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of Young People Aged 4-18 Years, and a comparison with the Survey of People Aged 65 Years and Over

被引:70
作者
Bates, CJ
Mansoor, MA
Gregory, J
Pentieva, K
Prentice, A
机构
[1] Elsie Widdowson Lab, MRC Human Nutr Res, Cambridge CB1 9NL, England
[2] Cent Hosp Rogaland, Dept Clin Chem, Stavanger, Norway
[3] Off Natl Stat, Social Survey Div, London SW1V 2QQ, England
[4] Univ Ulster, Sch Biomed Sci, No Ireland Ctr Diet & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland
基金
英国医学研究理事会;
关键词
homocysteine; National Diet and Nutrition Survey; vitamins; children;
D O I
10.1079/BJN2001479
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Plasma total homocysteine (tHcy), cysteine and csteinyl-glycine were measured in a representative sample of 922 young people aged 4-18 years, participating in the National Diet and Nutrition Survey in mainland Britain in 1997. Both tHcy and cysteine increased markedly with age; cysteinyl-glycine less so. Neither tHcy nor cysteine differed between genders; cysteinyl-glycine was higher in males. tHcy concentrations were lowest in the winter; cysteine and cysteinyl-glycine varied only slightly with season. In respondents aged > 15 years, tHcy was higher in smokers, but in respondents aged 7-11 years, tHcy was higher in those whose mothers smoked. tHcy was inversely correlated with serum folate, serum vitamin B-12 and vitamin B-6 status, but neither cysteine nor cysteinyl-glycine shared these relationships. The relationships between tHcy and B-vitamin status indices ran parallel with those of the 65 years and over survey, but at much lower tHcy concentrations for any given B-vitamin concentration. Age-adjusted tHcy was not correlated with anthropometric indices, blood pressure, haematology, plasma creatinine, urea or cholesterol, but was directly correlated with fasting triacylglycerol. We conclude that disease-risk indices, like tHcy and perhaps cysteine, if established during early life, may be modulated by diet and lifestyle, thereby providing an opportunity for public health intervention.
引用
收藏
页码:71 / 79
页数:9
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