p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells

被引：96

作者：

Blum, D ^{[1
]}

Wu, Y ^{[1
]}

Nissou, MF ^{[1
]}

Arnaud, S ^{[1
]}

Benabid, AL ^{[1
]}

Verna, JM ^{[1
]}

机构：

[1] CHU MICHALLON, INSERM U318, F-38043 GRENOBLE 9, FRANCE

来源：

BRAIN RESEARCH | 1997年 / 751卷 / 01期

关键词：

6-OHDA; apoptosis; PC12; Parkinson's disease; p53; Bax;

D O I：

10.1016/S0006-8993(96)01358-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

p53, Bax and Bcl-x(L) proteins have been implicated in apoptotic neuronal cell death. We have investigated whether those proteins are involved in 6-OHDA-induced PC12 cell death. After a 24-h exposure to the neurotoxin (100 mu M), morphological, evidence for apoptosis was observed in PC12 cells. Up-regulation of p53 and Bax proteins was demonstrated 4 and 6 h, respectively, after 6-OHDA treatment; in contrast, no change in Bcl-x(L) levels was found. These findings suggest that p53 and Bax could be relevant markers of neuronal apoptosis as previously described in kainic acid- or ischemia-induced neuronal cell death and may participate to neuronal degeneration in Parkinson's disease. (C) 1997 Elsevier Science B.V.

引用

页码：139 / 142

页数：4

共 22 条

[1]

ANGLADE P, 1995, SOC NEUR ABSTR, V21, P489

[2] THE BCL-2 FAMILY OF PROTEINS, AND THE REGULATION OF NEURONAL SURVIVAL [J].