Opinion - Functional mapping - how to map and study the genetic architecture of dynamic complex traits

被引:256
作者
Wu, RL [1 ]
Lin, M
机构
[1] Zhejiang Forestry Univ, Sch Forestry & Biotechnol, Linan 311300, Zhejiang, Peoples R China
[2] Univ Florida, Dept Stat, Gainesville, FL 32611 USA
[3] Duke Univ, Dept Biostat & Bioinformat, Durham, NC 27710 USA
基金
美国国家卫生研究院; 中国国家自然科学基金;
关键词
D O I
10.1038/nrg1804
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The development of any organism is a complex dynamic process that is controlled by a network of genes as well as by environmental factors. Traditional mapping approaches for analysing phenotypic data measured at a single time point are too simple to reveal the genetic control of developmental processes. A general statistical mapping framework, called functional mapping, has been proposed to characterize, in a single step, the quantitative trait loci (QTLs) or nucleotides (QTNs) that underlie a complex dynamic trait. Functional mapping estimates mathematical parameters that describe the developmental mechanisms of trait formation and expression for each QTL or QTN. The approach provides a useful quantitative and testable framework for assessing the interplay between gene actions or interactions and developmental changes.
引用
收藏
页码:229 / 237
页数:10
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