Asymmetric allylation of aldehydes catalyzed by substoichiometric amounts of chiral phosphoramides

被引:91
作者
Iseki, K [1 ]
Kuroki, Y [1 ]
Takahashi, M [1 ]
Kobayashi, Y [1 ]
机构
[1] DAIKIN IND LTD,MEC LAB,TSUKUBA,IBARAKI 305,JAPAN
关键词
D O I
10.1016/0040-4039(96)01040-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The asymmetric allylation and crotylation of aromatic aldehydes with allylic trichlorosilanes catalyzed by substoichiometric quantities of chiral phosphoramides were carried our with good enantiomeric excess (up to 88% ee). Phosphoramides 3 and 4, prepared from (S)-proline, gave chiral homoallylic alcohols 6 and their enantiomers 7, respectively, with similar levels of enantioselectivity. Copyright (C) 1996 Elsevier Science Ltd
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页码:5149 / 5150
页数:2
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