Parameters for reliable results in genetic association studies in common disease

被引：180

作者：

Dahlman, I

Eaves, IA

Kosoy, R

Morrison, VA

Heward, J

Gough, SCL

Allahabadia, A

Franklyn, JA

Tuomilehto, J

Tuomilehto-Wolf, E

Cucca, F

Guja, C

Ionescu-Tirgoviste, C

Stevens, H

Carr, P

Nutland, S

McKinney, P

Shield, JP

Wang, W

Cordell, HJ

Walker, N

Todd, JA

Concannon, P

机构：

[1] Univ Cambridge, Cambridge Inst Med Res, JDRF WF Diabet & Inflammat Lab, Cambridge CB2 2XY, England

[2] Univ Washington, Sch Med, Virginia Mason Res Ctr, Mol Genet Program, Seattle, WA USA

[3] Univ Washington, Sch Med, Dept Immunol, Seattle, WA USA

[4] Univ Birmingham, Birmingham Heartlands Hosp, Div Med Sci, Birmingham B9 5SS, W Midlands, England

[5] Univ Birmingham, Queen Elizabeth Hosp, Div Med Sci, Birmingham B9 5SS, W Midlands, England

[6] Natl Publ Hlth Inst, Diabet & Genet Epidemiol Unit, Helsinki, Finland

[7] Univ Helsinki, Dept Publ Hlth, Helsinki 00300, Finland

[8] Univ Cagliari, Dipartimento Sci Biobediche & Biotecnol, Cagliari, Italy

[9] Inst Diabet Nutr & Metab Dis N Paulescu, Diabet Clin, Bucharest, Romania

[10] Paediat Epidemiol Grp, Unit Epidemiol & HSR, Leeds, W Yorkshire, England

[11] Univ Bristol, Royal Hosp Sick Children, Inst Child Hlth, Bristol, Avon, England

来源：

NATURE GENETICS | 2002年 / 30卷 / 02期

基金：

芬兰科学院; 美国国家卫生研究院; 英国惠康基金;

关键词：

D O I：

10.1038/ng825

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.

引用

页码：149 / 150

页数：2

共 13 条

[1] Interleukin 12 and autoimmune diabetes [J].