Interleukin 12 and autoimmune diabetes

被引：40

作者：

Adorini, L ^{[1
]}

机构：

[1] Roche Milano Ric, I-20132 Milan, Italy

来源：

NATURE GENETICS | 2001年 / 27卷 / 02期

关键词：

D O I：

10.1038/84732

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18 has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B). This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases.

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页码：131 / 132

页数：2

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