Lipid Rafts & Co.: An integrated model of membrane organization in T cell activation

被引：58

作者：

Zeyda, Maximilan

Stulnig, Thomas M. ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, Vienna, Austria

[2] Ctr Mol Med, Vienna, Austria

来源：

PROGRESS IN LIPID RESEARCH | 2006年 / 45卷 / 03期

基金：

奥地利科学基金会;

关键词：

membrane microdomains; immunological synapse; single molecule tracking; T cell signaling;

D O I：

10.1016/j.plipres.2006.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The model of membrane compartmentalization by self-organizing functional lipid microdomains, named lipid rafts, has been a fruitful concept resulting in great progress in understanding T cell signal transduction. However, due to recent results it has become clear that lipid rafts describe only one out of several membrane organizing principles crucial for T cell activation besides fences and pickets and protein-protein interactions that take part in the formation of the immunological synapse as a highly organized structure at the T cell contact site to the antigen-presenting cell. This review describes the concepts of lipid rafts and other membrane organizing principles to evolve a novel integrated model on the functional role of microdomains in immunological synapse formation and T cell activation. Further research has to elucidate the relative contribution and interrelation of different modes of membrane organization in productive T cell activation. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：187 / 202

页数：16

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