Clinical Features, Diagnosis, and Natural History of Drug-Induced Liver Injury

Patients with idiosyncratic drug-induced liver injury (DILI) Can, pose substantial diagnostic, prognostic, and therapeutic challenges to the practicing gastroenterologist. The presentation of pm may vary from asymptomatic liver enzyme elevation to acute liver failure. Although most DILI resolves following drug discontinuation, up to 20% of patients progress: to chronic DILI further challenging the clinicians diagnostic and Management skills. Also, some medications can lead to advanced fibrosis, encephalopathy, and portal hypertension without significant elevation in liver enzymes during exposure, Finally; there are no objective tests to definitively diagnose DILI Although: causality assessment instruments are available, none are widely accepted or used in clinical practice. Therefore, the diagnosis of piu depends on thorough and accurate history taking, follow-up of the;patient's clinical course and excluding more common causes of liver injury. In this review, we discuss the variable clinical presentations, course, and diagnostic methods used to establish a diagnosis and prognosis in DILI.