Novel triazole 2′-deoxy-4′-thionucleosides:: Stereoselective synthesis and biological evaluation

被引：17

作者：

Inguaggiato, G

Jasamai, M

Smith, JE

Slater, M

Simons, C

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales

[2] Glaxo Wellcome Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 03期

关键词：

D O I：

10.1080/15257779908043089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A study on the use of protecting groups led to the employment of the para-methoxybenzoyl (pMB) group as a directing group in the synthesis of novel triazole 2'-deoxy-4'-thionucleosides. Use of the pMB group gave alpha:beta ratios of 1:6 in the glycosylation step with azidotrimethylsilane. A series of novel triazoles were generated for in vitro antiviral evaluation.

引用

页码：457 / 467

页数：11

共 5 条

[1]

DYSON MR, 1991, CARBOHYD RES, V216, P237

[2] Configurational assignment in 2'-deoxy-4'-thionucleosides - A review [J].