Acyl carbamate directing groups in nucleoside synthesis: Applications in the synthesis of 2'-deoxy-5-ethyl-4'-thiouridine

被引：14

作者：

ShawPonter, S

Mills, G

Robertson, M

Bostwick, RD

Hardy, GW

Young, RJ

机构：

[1] GLAXO WELLCOME MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

[2] CHEM DEV LABS,DARTFORD BR3 3BS,KENT,ENGLAND

[3] WELLCOME FDN LTD,DEPT MED CHEM,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 11期

关键词：

D O I：

10.1016/0040-4039(96)00138-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of the 3-O-(N-acyl)carbamoyl directing groups in the synthesis of the potent anti-Herpes virus agent 2'-deoxy-5-ethyl-4'-thio-D-uridine is described. This includes details of experiments to optimise the carbamate substitution and a multi-gram exemplification of the key steps.

引用

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页码：1867 / 1870

页数：4

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