Quantitative structure-activity relationship (QSAR) analysis for a series of rodent peroxisome proliferators: Interaction with the mouse liver peroxisome proliferator-activated receptor alpha (mPPAR alpha)

被引：7

作者：

Lewis, DFV ^{[1
]}

Lake, BG ^{[1
]}

机构：

[1] BRITISH IND BIOL RES ASSOC, CARSHALTON SM5 4DS, SURREY, ENGLAND

来源：

TOXICOLOGY IN VITRO | 1997年 / 11卷 / 1-2期

关键词：

D O I：

10.1016/S0887-2333(96)00067-7

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The results of quantitative structure-activity relationship (QSAR) analysis on a structurally diverse group of peroxisome proliferators are reported. The relative potencies of 11 peroxisome proliferators (with respect to clofibric acid) for induction of palmitoyl-CoA oxidation in rat hepatocyte cultures appear to be determined by a combination of lipophilicity (logP descriptor) and calculated binding affinity (logK) to a model of the mouse liver peroxisome proliferator-activated receptor a (mPPAR alpha) ligand-binding domain. It is possible that desolvation of the putative binding site and ligand ionization may also play a role in activation of the mPPAR alpha. (C) 1997 Elsevier Science Ltd.

引用

页码：99 / 105

页数：7

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