MECHANISTICALLY-BASED HUMAN HAZARD ASSESSMENT OF PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS

被引：226

作者：

ASHBY, J ^{[1
]}

BRADY, A ^{[1
]}

ELCOMBE, CR ^{[1
]}

ELLIOTT, BM ^{[1
]}

ISHMAEL, J ^{[1
]}

ODUM, J ^{[1
]}

TUGWOOD, JD ^{[1
]}

KETTLE, S ^{[1
]}

PURCHASE, IFH ^{[1
]}

机构：

[1] ZENECA LTD, TOXICOL LAB, MACCLESFIELD SK10 4TJ, CHESHIRE, ENGLAND

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷

关键词：

D O I：

10.1177/096032719401300201

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The conclusion of this review is that peroxisome proliferators constitute a discrete class of nongenotoxic rodent hepatocarcinogens and that the relevance of their hepatocarcinogenic effects for human hazard assessment is considered to be negligible.

引用

页码：S1 / S117

页数：117

共 425 条

[1] THE PRESENT LACK OF EVIDENCE FOR UNIQUE RODENT GERM-CELL MUTAGENS
ADLER, ID
ASHBY, J
[J]. MUTATION RESEARCH, 1989, 212 (01): : 55 - 66
[2] MUTAGENICITY EVALUATION OF PHTHALIC-ACID ESTERS AND METABOLITES IN SALMONELLA-TYPHIMURIUM CULTURES
AGARWAL, DK
LAWRENCE, WH
NUNEZ, LJ
AUTIAN, J
[J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1985, 16 (01): : 61 - 69
[3] AGARWAL DK, 1982, DRUG METAB DISPOS, V10, P77
[4] ALLEN KL, 1987, TOXICOLOGIST, V7
[5] IDENTIFICATION OF CYTOSOLIC PEROXISOME PROLIFERATOR BINDING-PROTEIN AS A MEMBER OF THE HEAT-SHOCK PROTEIN HSP70 FAMILY
ALVARES, K
CARRILLO, A
YUAN, PM
KAWANO, H
MORIMOTO, RI
REDDY, JK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) : 5293 - 5297
[6] AMACHER DE, 1983, CARCINOGENESIS, V4, P291
[7] AMACHER DE, 1985, PROGR MUTATION RES, V5, P487
[8] TOO MANY RODENT CARCINOGENS - MITOGENESIS INCREASES MUTAGENESIS
AMES, BN
GOLD, LS
[J]. SCIENCE, 1990, 249 (4972) : 970 - 971
[9] EARLY INDICATORS OF BLADDER CARCINOGENESIS PRODUCED BY NONGENOTOXIC AGENTS
ANDERSON, RL
[J]. MUTATION RESEARCH, 1991, 248 (02): : 261 - 270
[10] THE REGULATION OF EPIDERMAL HYPERPLASTIC GROWTH
ARGYRIS, TS
[J]. CRC CRITICAL REVIEWS IN TOXICOLOGY, 1981, 9 (02): : 151 - 200

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