MECHANISTICALLY-BASED HUMAN HAZARD ASSESSMENT OF PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS

被引：226

作者：

ASHBY, J ^{[1
]}

BRADY, A ^{[1
]}

ELCOMBE, CR ^{[1
]}

ELLIOTT, BM ^{[1
]}

ISHMAEL, J ^{[1
]}

ODUM, J ^{[1
]}

TUGWOOD, JD ^{[1
]}

KETTLE, S ^{[1
]}

PURCHASE, IFH ^{[1
]}

机构：

[1] ZENECA LTD, TOXICOL LAB, MACCLESFIELD SK10 4TJ, CHESHIRE, ENGLAND

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷

关键词：

D O I：

10.1177/096032719401300201

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The conclusion of this review is that peroxisome proliferators constitute a discrete class of nongenotoxic rodent hepatocarcinogens and that the relevance of their hepatocarcinogenic effects for human hazard assessment is considered to be negligible.

引用

页码：S1 / S117

页数：117

共 425 条

[31] HEPATIC PEROXISOME PROLIFERATION IN RODENTS AND ITS SIGNIFICANCE FOR HUMANS
BENTLEY, P
CALDER, I
ELCOMBE, C
GRASSO, P
STRINGER, D
WIEGAND, HJ
[J]. FOOD AND CHEMICAL TOXICOLOGY, 1993, 31 (11) : 857 - 907
[32] BENTLEY P, IN PRESS FOOD CHEM T
[33] BENTLEY P, 1987, PEROXISOMES BIOL MED, P309
[34] ALKYLTHIO ACETIC-ACIDS (3-THIA FATTY-ACIDS) - A NEW GROUP OF NON-BETA-OXIDIZABLE PEROXISOME-INDUCING FATTY-ACID ANALOGS .2. DOSE-RESPONSE STUDIES ON HEPATIC PEROXISOMAL CHANGES AND MITOCHONDRIAL CHANGES AND LONG-CHAIN FATTY-ACID METABOLIZING ENZYMES IN RATS
BERGE, RK
AARSLAND, A
KRYVI, H
BREMER, J
AARSAETHER, N
[J]. BIOCHEMICAL PHARMACOLOGY, 1989, 38 (22) : 3969 - 3979
[35] APPLICATION AND RESULTS OF WHOLE-BODY AUTORADIOGRAPHY IN DISTRIBUTION STUDIES OF ORGANIC-SOLVENTS
BERGMAN, K
[J]. CRC CRITICAL REVIEWS IN TOXICOLOGY, 1983, 12 (01): : 59 - 118
[36] RELATIVE GENOTOXICITY OF TRICHLOROACETIC-ACID (TCA) AS REVEALED BY DIFFERENT CYTOGENETIC ASSAYS - BONE-MARROW CHROMOSOME ABERRATION, MICRONUCLEUS AND SPERM-HEAD ABNORMALITY IN THE MOUSE
BHUNYA, SP
BEHERA, BC
[J]. MUTATION RESEARCH, 1987, 188 (03): : 215 - 221
[37] TOXICOLOGICAL STUDIES ON A BENZOFURAN DERIVATIVE .3. COMPARISON OF PEROXISOME PROLIFERATION IN RAT AND HUMAN HEPATOCYTES IN PRIMARY CULTURE
BICHET, N
CAHARD, D
FABRE, G
REMANDET, B
GOUY, D
CANO, JP
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1990, 106 (03) : 509 - 517
[38] RELATIONSHIP BETWEEN CHEMICAL-STRUCTURE AND MUTAGENIC ACTIVITY IN SOME PESTICIDES - USE OF SALMONELLA-TYPHIMURIUM AND ASPERGILLUS-NIDULANS
BIGNAMI, M
CARDAMONE, G
COMBA, P
ORTALI, VA
MORPURGO, G
CARERE, A
[J]. MUTATION RESEARCH, 1977, 46 (03): : 243 - 244
[39] BISHOP JB, 1987, ENVIRON MOL MUTAGEN, V9, P15
[40] THE EFFECT OF BECLOBRIC ACID AND CLOFIBRIC ACID ON PEROXISOMAL BETA-OXIDATION AND PEROXISOME PROLIFERATION IN PRIMARY CULTURES OF RAT, MONKEY AND HUMAN HEPATOCYTES
BLAAUBOER, BJ
VANHOLSTEIJN, CWM
BLEUMINK, R
MENNES, WC
VANPELT, FNAM
YAP, SH
VANPELT, JF
VANIERSEL, AAJ
TIMMERMAN, A
SCHMID, BP
[J]. BIOCHEMICAL PHARMACOLOGY, 1990, 40 (03) : 521 - 528

← 1 2 3 4 5 6 7 8 9 10 →