MECHANISTICALLY-BASED HUMAN HAZARD ASSESSMENT OF PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS

被引：226

作者：

ASHBY, J ^{[1
]}

BRADY, A ^{[1
]}

ELCOMBE, CR ^{[1
]}

ELLIOTT, BM ^{[1
]}

ISHMAEL, J ^{[1
]}

ODUM, J ^{[1
]}

TUGWOOD, JD ^{[1
]}

KETTLE, S ^{[1
]}

PURCHASE, IFH ^{[1
]}

机构：

[1] ZENECA LTD, TOXICOL LAB, MACCLESFIELD SK10 4TJ, CHESHIRE, ENGLAND

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷

关键词：

D O I：

10.1177/096032719401300201

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The conclusion of this review is that peroxisome proliferators constitute a discrete class of nongenotoxic rodent hepatocarcinogens and that the relevance of their hepatocarcinogenic effects for human hazard assessment is considered to be negligible.

引用

页码：S1 / S117

页数：117

共 425 条

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