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The role of general initiation factors in transcription by RNA polymerase II

被引：472
作者：
Roeder, RG
机构：
[1] Lab. of Biochem. and Molec. Biology, Rockefeller University, New York
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0968-0004(96)10050-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcription initiation on protein-encoding genes represents a major control point for gene expression in eukaryotes, and is mediated by RNA polymerase II and a surprisingly complex array of general initiation factors (TFIIA, -B, -D, E, -F and -H) that are highly conserved from yeast to man. Elucidation of structural and functional features of these factors on model promoters has revealed insights into biochemical mechanisms and provides a basis for understanding their regulation on diverse promoters by gene- and cell-specific activators.
引用
收藏
页码：327 / 335
页数：9
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