Major histocompatibility complex class II I-E-independent transmission of C3H mouse mammary tumor virus

被引：17

作者：

Wrona, T ^{[1
]}

Dudley, JP ^{[1
]}

机构：

[1] UNIV TEXAS,DEPT MICROBIOL,AUSTIN,TX 78712

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 02期

关键词：

D O I：

10.1128/JVI.70.2.1246-1249.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

C57/BL/6 mice are resistant to C3H mouse mammary tumor virus (MMTV)-induced mammary tumorigenesis and lack major histocompatibility complex class II I-E molecules that are essential for presentation of C3H superantigen to T cells. T cells are needed for transmission of milk-borne MMTV from the gut to the mammary gland. In this report, we show that infectious C3H MMTV is produced by C57BL/6 mice that nurse on C3H mothers but that virus production in the mammary gland is delayed compared with that in I-E(+) mouse strains.

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页码：1246 / 1249

页数：4

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