Recent progress in tumor pH targeting nanotechnology

被引：753

作者：

Lee, Eun Seong ^{[1
,2
]}

Gao, Zhonggao ^{[1
]}

Bae, You Han ^{[1
]}

机构：

[1] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA

[2] Catholic Univ Korea, Div Biotechnol, Bucheon Si 420743, South Korea

来源：

JOURNAL OF CONTROLLED RELEASE | 2008年 / 132卷 / 03期

关键词：

Tumor extracellular pH; Endosomal pH; pH double targeting; Micelle; Nanogel; Block copolymers; Sulfonamide; Histidine;

D O I：

10.1016/j.jconrel.2008.05.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

pH-sensitive polymeric micelles and nanogels have recently been developed to target slightly acidic extracellular pH environment of solid tumors. The pH targeting approach is regarded as a more general strategy than conventional specific tumor cell surface targeting approaches, because the acidic tumor microclimate is most common in solid tumors. When nanosystems are combined with triggered release mechanisms by endosomal or lysosomal acidity plus endosomolytic capability, the nanocarriers demonstrated to overcome multidrug resistance of various tumors. This review highlights recent progress of the pH-sensitive nanotechnology developed in Bae research group. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：164 / 170

页数：7

共 106 条

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