Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change

被引：1157

作者：

Bae, Y ^{[1
]}

Fukushima, S ^{[1
]}

Harada, A ^{[1
]}

Kataoka, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 38期

关键词：

anticancer agents; micelles; polymers; self-assembly; supramolecular chemistry;

D O I：

10.1002/anie.200250653

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug smuggling: Micelles made up of block copolymers and the anticancer drug adriamycin (ADR), which is linked to the polymer by a pH-sensitive linker, have been prepared (see picture). Treatment of cancer cells with the micelles shows that the micelles are transported into the cell by endocytosis, thus bypassing the cell-membrane transporters. In the cell, the decrease in pH value triggers the release of the ADR, which retains its cytotoxic effect. The released ADR fluoresces which allows its localization within the cells to be detected.

引用

页码：4640 / 4643

页数：4

共 27 条

[1] Polymer vesicles
Discher, DE
Eisenberg, A
[J]. SCIENCE, 2002, 297 (5583) : 967 - 973
[2] DRUG POLYMER CONJUGATES - POTENTIAL FOR IMPROVED CHEMOTHERAPY
DUNCAN, R
[J]. ANTI-CANCER DRUGS, 1992, 3 (03) : 175 - 210
[3] Biomedicine - The NASA-NCI collaboration on biomolecular sensors
Goldin, DS
Dahl, CA
Olsen, KL
Ostrach, LH
Klausner, RD
[J]. SCIENCE, 2001, 292 (5516) : 443 - 444
[4] Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium
Harada, A
Kataoka, K
[J]. MACROMOLECULES, 1998, 31 (02) : 288 - 294
[5] Polyester dendritic systems for drug delivery applications:: Design, synthesis, and characterization
Ihre, HR
De Jesüs, OLP
Szoka, FC
Fréchet, JMJ
[J]. BIOCONJUGATE CHEMISTRY, 2002, 13 (03) : 443 - 452
[6] Environment-sensitive stabilization of core-shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond
Kakizawa, Y
Harada, A
Kataoka, K
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (48) : 11247 - 11248
[7] NEW HYDRAZONE DERIVATIVES OF ADRIAMYCIN AND THEIR IMMUNOCONJUGATES - A CORRELATION BETWEEN ACID STABILITY AND CYTOTOXICITY
KANEKO, T
WILLNER, D
MONKOVIC, I
KNIPE, JO
BRASLAWSKY, GR
GREENFIELD, RS
VYAS, DM
[J]. BIOCONJUGATE CHEMISTRY, 1991, 2 (03) : 133 - 141
[8] KATAOKA K, 1993, J CONTROL RELEASE, V24, P119
[9] Spontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline
Kataoka, K
Togawa, H
Harada, A
Yasugi, K
Matsumoto, T
Katayose, S
[J]. MACROMOLECULES, 1996, 29 (26) : 8556 - 8557
[10] Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K
Harada, A
Nagasaki, Y
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) : 113 - 131

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