(E)-5-tosyl-4-pentenamide: A vinyl sulfone for the one-pot general synthesis of indolizidine derivatives

被引：13

作者：

Caturla, F ^{[1
]}

Najera, C ^{[1
]}

机构：

[1] UNIV ALICANTE,FAC CIENCIAS,DEPT QUIM ORGAN,ALICANTE 03080,SPAIN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(97)00736-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(E)-5-tosyl-4-pentenamide (3), easily prepared from 4-pentenoic acid by stereoselective iodosulfonylation-dehydroiodination and further amidation with oxalyl chloride and ammonia, reacts with sodium hydride at room temperature in DMF and then with 1,3-dielectrophiles such as 1,3-dihalides and alpha,beta-unsaturated esters to provide stereoselectively differently substituted indolizidines 6. (C) 1997 Elsevier Science Ltd.

引用

页码：3789 / 3792

页数：4

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