A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

被引：123

作者：

Wang, Danling ^{[1
]}

Wang, Jianing ^{[1
]}

Bonamy, Ghislain M. C. ^{[2
]}

Meeusen, Shelly ^{[2
]}

Brusch, Richard G. ^{[2
]}

Turk, Carolina ^{[2
]}

Yang, Pengyu ^{[1
]}

Schultz, Peter G. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 37期

关键词：

ATP synthase; drug design; mitochondrial fusion; phenotypic screening; CYTOCHROME-C RELEASE; DISEASE IMPLICATIONS; FISSION; PROTEIN; DYNAMICS; FRAGMENTATION; NEURONS; SIGNALS; PINK1; OUTER;

D O I：

10.1002/anie.201204589

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mitochondrial dynamics: An image-based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial-fragmentation-associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance towards fusion (see picture). © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9302 / 9305

页数：4

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