Native chemical ligation at valine

被引：257

作者：

Haase, Christian ^{[1
]}

Rohde, Heike ^{[1
]}

Seitz, Oliver ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 36期

关键词：

native chemical ligation; penicillamine; peptide ligation; valine;

D O I：

10.1002/anie.200801590

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Peptide ligation at hydrophobic sites is possible with a ligation-desulfurization strategy in which penicillamine serves as a precursor of valine. The β,β-dimethylcysteine peptides reacted surprisingly fast in native chemical ligation reactions. Even the sterically crowded and unpolar Leu-Val bond can be formed in high yield. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：6807 / 6810

页数：4

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