Imaging pulsatile retinal blood flow in human eye

被引:36
作者
Rao, Bin [1 ,2 ]
Yu, Lingfeng [2 ]
Chiang, Huihua Kenny [4 ]
Zacharias, Leandro C. [3 ]
Kurtz, Ronald M. [3 ]
Kuppermann, Baruch D. [3 ]
Chen, Zhongping [1 ,2 ]
机构
[1] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92717 USA
[2] Beckman Laser Inst & Med Clin, Irvine, CA 92617 USA
[3] Dept Ophthalmol, Irvine, CA 92612 USA
[4] Yang Ming Univ, Inst Biomed Engn, Taipei 112, Taiwan
基金
美国国家卫生研究院;
关键词
doppler; tomography; interferometry;
D O I
10.1117/1.2967986
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A functional Fourier domain optical coherence tomography instrument offering spectral Doppler imaging of in vivo pulsatile human retinal blood flow was constructed. An improved phase-resolved algorithm was developed to correct bulk motion artifacts. Spectral Doppler imaging provides complementary temporal flow information to the spatially distributed flow information of the color Doppler image by providing direct visualization of the Doppler spectrum of the flow whose pattern can be further quantified with various velocity envelope curves and their corresponding flow indices. The coefficient of repeatability on resistance index measurement was assessed by analyzing 14 measurements on two vessels within two normal subjects. (C) 2008 Society of Photo-Optical Instrumentation Engineers.
引用
收藏
页数:3
相关论文
共 18 条
[1]   STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].
BLAND, JM ;
ALTMAN, DG .
LANCET, 1986, 1 (8476) :307-310
[2]   Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography [J].
Chen, ZP ;
Milner, TE ;
Srinivas, S ;
Wang, XJ ;
Malekafzali, A ;
vanGemert, MJC ;
Nelson, JS .
OPTICS LETTERS, 1997, 22 (14) :1119-1121
[3]   The impact of ocular blood flow in glaucoma [J].
Flammer, J ;
Orgül, S ;
Costa, VP ;
Orzalesi, N ;
Krieglstein, GK ;
Serra, LM ;
Renard, JP ;
Stefánsson, E .
PROGRESS IN RETINAL AND EYE RESEARCH, 2002, 21 (04) :359-393
[4]   Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension [J].
Fuchsjäger-Mayrl, G ;
Wally, B ;
Georgopoulos, M ;
Rainer, G ;
Kircher, K ;
Buehl, W ;
Amoako-Mensah, T ;
Eichler, HG ;
Vass, C ;
Schmetterer, L .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (03) :834-839
[5]   In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomograghy [J].
Izatt, JA ;
Kulkami, MD ;
Yazdanfar, S ;
Barton, JK ;
Welch, AJ .
OPTICS LETTERS, 1997, 22 (18) :1439-1441
[6]   Registration of high-density cross sectional images to the fundus image in spectral-domain ophthalmic optical coherence tomography [J].
Jiao, SL ;
Wu, CY ;
Knighton, RW ;
Gregori, G ;
Puliafito, CA .
OPTICS EXPRESS, 2006, 14 (08) :3368-3376
[7]   Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography [J].
Leitgeb, RA ;
Schmetterer, L ;
Drexler, W ;
Fercher, AF ;
Zawadzki, RJ ;
Bajraszewski, T .
OPTICS EXPRESS, 2003, 11 (23) :3116-3121
[8]   Optical coherence angiography [J].
Makita, Shuichi ;
Hong, Youngjoo ;
Yamanari, Masahiro ;
Yatagai, Toyohiko ;
Yasuno, Yoshiaki .
OPTICS EXPRESS, 2006, 14 (17) :7821-7840
[9]  
Maulik D, 2005, DOPPLER ULTRASOUND O
[10]   RETINAL BLOOD-FLOW IN DIABETIC-RETINOPATHY [J].
PATEL, V ;
RASSAM, S ;
NEWSOM, R ;
WIEK, J ;
KOHNER, E .
BMJ-BRITISH MEDICAL JOURNAL, 1992, 305 (6855) :678-683