Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates

被引:72
作者
Zhang, Zhao [1 ,2 ,3 ]
Liu, Jun [2 ]
Li, Meng [2 ]
Yang, Hui [1 ]
Zhang, Chiyu [2 ,3 ]
机构
[1] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
[2] Jiangsu Univ, Inst Life Sci, Zhenjiang, Jiangsu, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Pasteur Shanghai, Diagnost Ctr Pathogens, Shanghai, Peoples R China
来源
PLOS ONE | 2012年 / 7卷 / 11期
基金
中国国家自然科学基金;
关键词
NONHUMAN PRIMATE MODEL; MARMOSETS CALLITHRIX-JACCHUS; RESTRICTION FACTOR SAMHD1; VIRUS-B INFECTION; WEST NILE VIRUS; IMMUNODEFICIENCY-VIRUS; PROCESSED PSEUDOGENES; EXPRESSION; IFITM3; PROTEINS;
D O I
10.1371/journal.pone.0049265
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Vertebrate interferon-induced transmembrane (IFITM) genes have been demonstrated to have extensive and diverse functions, playing important roles in the evolution of vertebrates. Despite observance of their functionality, the evolutionary dynamics of this gene family are complex and currently unknown. Here, we performed detailed evolutionary analyses to unravel the evolutionary history of the vertebrate IFITM family. A total of 174 IFITM orthologous genes and 112 pseudogenes were identified from 27 vertebrate genome sequences. The vertebrate IFITM family can be divided into immunity-related IFITM (IR-IFITM), IFITM5 and IFITM10 sub-families in phylogeny, implying origins from three different progenitors. In general, vertebrate IFITM genes are located in two loci, one containing the IFITM10 gene, and the other locus containing IFITM5 and various numbers of IR-IFITM genes. Conservation of evolutionary synteny was observed in these IFITM genes. Significant functional divergence was detected among the three IFITM sub-families. No gene duplication or positive selection was found in IFITM5 sub-family, implying the functional conservation of IFITM5 in vertebrate evolution, which is involved in bone formation. No IFITM5 locus was identified in the marmoset genome, suggesting a potential association with the tiny size of this monkey. The IFITM10 sub-family was divided into two groups: aquatic and terrestrial types. Functional divergence was detected between the two groups, and five IFITM10-like genes from frog were dispersed into the two groups. Both gene duplication and positive selection were observed in aquatic vertebrate IFITM10-like genes, indicating that IFITM10 might be associated with the adaptation to aquatic environments. A large number of lineage-and species-specific gene duplications were observed in IR-IFITM sub-family and positive selection was detected in IR-IFITM of primates and rodents. Because primates have experienced a long history of viral infection, such rapid expansion and positive selection suggests that the evolution of primate IR-IFITM genes is associated with broad-spectrum antiviral activity.
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页数:13
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