Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma

被引：130

作者：

Abnet, Christian C. ^{[1
]}

Kamangar, Farin ^{[1
]}

Islami, Farhad ^{[2
,3
]}

Nasrollahzadeh, Dariush ^{[3
]}

Brennan, Paul ^{[3
]}

Aghcheli, Karim ^{[2
]}

Merat, Shahin ^{[2
]}

Pourshams, Akram ^{[2
]}

Marjani, Haj Amin ^{[2
]}

Ebadati, Abdolhakim ^{[2
]}

Sotoudeh, Masoud ^{[2
]}

Boffetta, Paolo ^{[3
]}

Malekzadeh, Reza ^{[2
]}

Dawsey, Sanford M. ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Nutr Epidemiol Branch, Rockville, MD 20852 USA

[2] IARC, Lyon, France

[3] Univ Tehran Med Sci, Digest Dis Res Ctr, Tehran, Iran

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2008年 / 17卷 / 11期

关键词：

D O I：

10.1158/1055-9965.EPI-08-0558

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases (n = 283) and controls (n = 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth (DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P = 0.0045). Subjects with ESCC were significantly more likely than controls to fail to practice regular oral hygiene (78% versus 58%). In multivariate-adjusted conditional logistic regression models, having 32 DMFT compared with <= 15 conferred an odds ratio (95% confidence interval) of 2.10 (1.19-3.70). Compared with daily tooth brushing, practicing no regular oral hygiene conferred an odds ratio (95% confidence interval) of 2.37 (1.42-3.97). Restricting the analysis to subjects that had never smoked tobacco did not materially alter these results. We found significant associations between two markers of poor oral hygiene, a larger number of DMFT and lack of daily tooth brushing, and risk of ESCC in a population at high risk for ESCC where many cases occur in never smokers. Our results are consistent with several previous analyses in other high-risk populations. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3062-8)

引用

页码：3062 / 3068

页数：7