共 55 条
Bacterial entry into cells: A role for the endocytic machinery
被引:57
作者:
Bonazzi, Matteo
Cossart, Pascale
[1
]
机构:
[1] Inst Pasteur, Unite Interact Bacteries Cellules, F-75015 Paris, France
[2] INSERM, U604, F-75015 Paris, France
[3] INRA, USC2020, F-75015 Paris, France
来源:
FEBS LETTERS
|
2006年
/
580卷
/
12期
关键词:
pathogens;
endocytosis;
signalling;
Listeria monocytogenes;
D O I:
10.1016/j.febslet.2006.04.010
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Increasing evidence indicates that pathogens have evolved highly efficient strategies to induce their internalization within host cells. Viruses and bacteria express and expose on their surface, molecules that mimic endogenous ligands to cell receptors, thereby inducing specific intracellular signalling cascades. More recently it has become clear that, as most viruses, bacteria can enter cells via the clathrin-mediated pathway, indicating a key role for endocytosis in pathogens entry into cells. Here we review the pathways followed by Listeria monocytogenes to enter into non-phagocytic cells, as a model for the subversion of cellular functions to induce pathogens internalization. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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页码:2962 / 2967
页数:6
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