Bacterial invasion: The paradigms of enteroinvasive pathogens

被引:746
作者
Cossart, P
Sansonetti, PJ
机构
[1] Inst Pasteur, INSERM, U604, Unite Interact Bacteries Cellules, F-75015 Paris, France
[2] Inst Pasteur, Dept Biol Cellulaire & Infect, CNRS, U389,Unite Pathogenie Microbienne Mol, F-75015 Paris, France
关键词
D O I
10.1126/science.1090124
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Invasive bacteria actively induce their own uptake by phagocytosis in normally nonphagocytic cells and then either establish a protected niche within which they survive and replicate, or disseminate from cell to cell by means of an actin-based motility process. The mechanisms underlying bacterial entry, phagosome maturation, and dissemination reveal common strategies as well as unique tactics evolved by individual species to establish infection.
引用
收藏
页码:242 / 248
页数:7
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