The Discovery and Development of Smac Mimetics-Small-Molecule Antagonists of the Inhibitor of Apoptosis Proteins

被引：11

作者：

Condon, Stephen M. ^{[1
]}

机构：

[1] TetraLog Pharmaceut, Malvern, PA 19355 USA

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 46 | 2011年 / 46卷

关键词：

NF-KAPPA-B; X-LINKED INHIBITOR; ALPHA-DEPENDENT APOPTOSIS; TNF-ALPHA; IAP ANTAGONISTS; BIOCHEMICAL BASIS; CANCER-CELLS; XIAP; ACTIVATION; SMAC/DIABLO;

D O I：

10.1016/B978-0-12-386009-5.00014-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：211 / 226

页数：16

共 54 条

[1]

Amaravadi R. K., 2011, 102 AACR M ORL FL US

[2] Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2 [J].

Bertrand, Mathieu J. M. ;

Doiron, Karine ;

Labbe, Katherine ;

Korneluk, Robert G. ;

Barker, Philip A. ;

Saleh, Maya .

IMMUNITY, 2009, 30 (06) :789-801

[3]

Betrand M. J. M., 2008, MOL CELL, V30, P689

[4] A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment [J].

Cai, Qian ;

Sun, Haiying ;

Peng, Yuefeng ;

Lu, Jianfeng ;

Nikolovska-Coleska, Zaneta ;

McEachern, Donna ;

Liu, Liu ;

Qiu, Su ;

Yang, Chao-Yie ;

Miller, Rebecca ;

Yi, Han ;

Zhang, Tao ;

Sun, Duxin ;

Kang, Sanmao ;

Guo, Ming ;

Leopold, Lance ;

Yang, Dajun ;

Wang, Shaomeng .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (08) :2714-2726

[5] Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML [J].

Carter, Bing Z. ;

Mak, Duncan H. ;

Schober, Wendy D. ;

Koller, Erich ;

Pinilla, Clemencia ;

Vassilev, Lyubomir T. ;

Reed, John C. ;

Andreeff, Michael .

BLOOD, 2010, 115 (02) :306-314

[6] Structural and biochemical basis of apoptotic activation by Smac/DIABLO [J].

Chai, JJ ;

Du, CY ;

Wu, JW ;

Kyin, S ;

Wang, XD ;

Shi, YG .

NATURE, 2000, 406 (6798) :855-862

[7] Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM) [J].

Chauhan, Dharminder ;

Neri, Paola ;

Velankar, Mugdha ;

Podar, Klaus ;

Hideshima, Teru ;

Fulciniti, Mariateresa ;

Tassone, Pierfrancesco ;

Raje, Noopur ;

Mitsiades, Constantine ;

Mitsiades, Nicholas ;

Richardson, Paul ;

Zawel, Leigh ;

Tran, Mary ;

Munshi, Nikhil ;

Anderson, Kenneth C. .

BLOOD, 2007, 109 (03) :1220-1227

[8] Orally Bioavailable Antagonists of Inhibitor of Apoptosis Proteins Based on an Azabicyclooctane Scaffold [J].

Cohen, Frederick ;

Alicke, Bruno ;

Elliott, Linda O. ;

Flygare, John A. ;

Goncharov, Tatiana ;

Keteltas, Stephen F. ;

Franklin, Matthew C. ;

Frankovitz, Stacy ;

Stephan, Jean-Philippe ;

Tsui, Vickie ;

Vucic, Domagoj ;

Wong, Harvey ;

Fairbrother, Wayne J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (06) :1723-1730

[9]

Condon S. M., 2006, 232 ACS NAT M SAN FR

[10]

Condon S. M., 2009, U.S. Patent, Patent No. 7517906

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