The Discovery and Development of Smac Mimetics-Small-Molecule Antagonists of the Inhibitor of Apoptosis Proteins

被引：11

作者：

Condon, Stephen M. ^{[1
]}

机构：

[1] TetraLog Pharmaceut, Malvern, PA 19355 USA

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 46 | 2011年 / 46卷

关键词：

NF-KAPPA-B; X-LINKED INHIBITOR; ALPHA-DEPENDENT APOPTOSIS; TNF-ALPHA; IAP ANTAGONISTS; BIOCHEMICAL BASIS; CANCER-CELLS; XIAP; ACTIVATION; SMAC/DIABLO;

D O I：

10.1016/B978-0-12-386009-5.00014-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：211 / 226

页数：16

共 54 条

[11] Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival [J].

Conte, D ;

Holcik, M ;

Lefebvre, CA ;

LaCasse, E ;

Picketts, DJ ;

Wright, KE ;

Korneluk, RG .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (02) :699-708

[12] Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo [J].

Conze, DB ;

Albert, L ;

Ferrick, DA ;

Goeddel, DV ;

Yeh, WC ;

Mak, T ;

Ashwell, JD .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (08) :3348-3356

[13]

Dai Y, 2009, AM J TRANSL RES, V1, P1

[14]

Dueber E. C., 2010, ESH INT C MECH CELL

[15] cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand [J].

Dupoux, Alban ;

Cartier, Jessy ;

Cathelin, Severine ;

Filomenko, Rodolphe ;

Solary, Eric ;

Dubrez-Daloz, Laurence .

BLOOD, 2009, 113 (01) :175-185

[16]

Eckhardt S. G., 2010, ASCO ANN M CHIC IL U

[17] Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization [J].

Feltham, Rebecca ;

Bettjeman, Bodhi ;

Budhidarmo, Rhesa ;

Mace, Peter D. ;

Shirley, Sarah ;

Condon, Stephen M. ;

Chunduru, Srinivas K. ;

McKinlay, Mark A. ;

Vaux, David L. ;

Silke, John ;

Day, Catherine L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (19) :17015-17028

[18] A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-α signaling [J].

Gaither, Alex ;

Porter, Dale ;

Yao, Yao ;

Borawski, Jason ;

Yang, Guang ;

Donovan, Jerry ;

Sage, David ;

Slisz, Joanna ;

Tran, Mary ;

Straub, Christopher ;

Ramsey, Tim ;

Iourgenko, Vadim ;

Huang, Alan ;

Chen, Yan ;

Schlegel, Robert ;

Labow, Mark ;

Fawell, Stephen ;

Sellers, William R. ;

Zawel, Leigh .

CANCER RESEARCH, 2007, 67 (24) :11493-11498

[19] IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis [J].

Gyrd-Hansen, Mads ;

Darding, Maurice ;

Miasari, Maria ;

Santoro, Massimo M. ;

Zender, Lars ;

Xue, Wen ;

Tenev, Tencho ;

da Fonseca, Paula C. A. ;

Zvelebil, Marketa ;

Bujnicki, Janusz M. ;

Lowe, Scott ;

Silke, John ;

Meier, Pascal .

NATURE CELL BIOLOGY, 2008, 10 (11) :1309-U130

[20] IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer [J].

Gyrd-Hansen, Mads ;

Meier, Pascal .

NATURE REVIEWS CANCER, 2010, 10 (08) :561-574

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