LINGO-1 and its role in CNS repair

被引：101

作者：

Mi, Sha ^{[1
]}

Sandrock, Alfred

Miller, Robert H. ^{[2
]}

机构：

[1] Biogen Idec Inc, Dept Discovery Neurobiol, Cambridge, MA 02142 USA

[2] Case Western Reserve Univ, Sch Med, Dept Neurosci, Ctr Translat Neurosci, Cleveland, OH 44106 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2008年 / 40卷 / 10期

关键词：

LINGO-1. CNS diseases; regeneration; remyelination;

D O I：

10.1016/j.biocel.2008.03.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LINGO-1 is selectively expressed in the CNS on both oligodendrocyte precursor cells (OPCs) and neurons. Its expression is developmentally regulated in the normal CNS, as well as up-regulated in human or rat models of neuropathologies. LINGO-I functions as a negative regulator of oligodendrocyte differentiation and myelination, neuronal survival and axonal regeneration. Across diverse animal CNS disease models, targeted LINGO-1 inhibition was found to promote neuron and oligodendrocyte survival, axon regeneration, oligodendrocyte differentiation, remyelination and improved functional recovery. The targeted inhibition of LINGO-1 therefore presents a novel therapeutic approach for the treatment of neurological diseases. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1971 / 1978

页数：8

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