Synthesis of C1-C8 and C9-C24 fragments of (-)-discodermolide: use of asymmetric alkylation and stereoselective aldol reactions

被引：29

作者：

Filla, SA ^{[1
]}

Song, JJ ^{[1
]}

Chen, LR ^{[1
]}

Masamune, S ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 30期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)01009-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C1-C8 and C9-C24 fragments of (-)-discodermolide, the antipode of the marine natural product (+)discodermolide, have been synthesized with excellent stereoselectivities. These syntheses feature the utilization of the isoxazolidine-mediated asymmetric alkylation methodology and fragment-fragment coupling aldol reactions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：5449 / 5453

页数：5

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