Multiclass method for fast determination of veterinary drug residues in baby food by ultra-high-performance liquid chromatography-tandem mass spectrometry

被引：90

作者：

Aguilera-Luiz, M. M. ^{[1
]}

Martinez Vidal, J. L. ^{[1
]}

Romero-Gonzalez, R. ^{[1
]}

Garrido Frenich, A. ^{[1
]}

机构：

[1] Almeria Univ, Dept Analyt Chem, Grp Analyt Chem Contaminants, E-04071 Almeria, Spain

来源：

FOOD CHEMISTRY | 2012年 / 132卷 / 04期

关键词：

Multiclass veterinary drugs; Powdered milk-based infant formulae; Meat-based baby food; QuEChERS; UHPLC-MS/MS; SOLID-PHASE EXTRACTION; MULTIRESIDUE METHOD; PESTICIDE-RESIDUES; SAMPLE PREPARATION; ANTIBIOTICS; MEAT; FLUOROQUINOLONE; SULFONAMIDE; VALIDATION; MUSCLE;

D O I：

10.1016/j.foodchem.2011.12.042

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple and rapid multiresidue method for the determination of different veterinary drug residues in meat-based baby food (MBF) and powdered milk-based infant formulae (PMIF) has been developed. The method involves an extraction procedure based on buffered QuEChERS (quick, easy, cheap, effective, rugged and safe) methodology, without any further clean-up step, followed by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). The method has been validated in two baby food matrices (MBF and PMIF) at three different concentration levels, obtaining suitable recoveries and precision (inter and intra-day precision) values. Quantification was carried out using matrix-matched standard calibration. Furthermore, the decision limit (CC alpha) and the decision capability (CC beta) were evaluated, ranging from 0.5 to 16.2 mu g/kg and from 1.2 to 22.4 mu g/kg, respectively. Finally, the method was applied to the analysis of several kinds of baby food samples and traces of some veterinary drugs were detected. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2171 / 2180

页数：10

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