Cyclooxygenase-1 and -2 isoenzymes

被引：184

作者：

Hla, T ^{[1
]}

Bishop-Bailey, D ^{[1
]}

Liu, CH ^{[1
]}

Schaefers, HJ ^{[1
]}

Trifan, OC ^{[1
]}

机构：

[1] Univ Connecticut, Sch Med,Hlth Ctr, Dept Physiol, Ctr Vasc Biol, Farmington, CT 06030 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1999年 / 31卷 / 05期

关键词：

D O I：

10.1016/S1357-2725(98)00152-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cyclooxygenase isoenzymes (COX-1 and -2) catalyze the rate-limiting steps in prostanoid biosynthesis. COX-1 and -2 genes encode two isoenzymes with overlapping yet distinct expression patterns and functions. Physiologically, various extracellular stimuli such as growth factors, cytokines and tumor promoters regulate the expression of COX-1 and -2 genes at both transcriptional and post-transcriptional levels. COX-2 is overexpressed in rheumatoid arthritis, colorectal and breast cancer. Prostanoids produced by the COX pathway signal via plasma membrane-localized, G-protein-coupled receptors as well as via nuclear receptors, Currently, several COX-2-selective inhibitors are developed to control the anti-inflammatory and anti-neoplastic activities of the COX-2 isoenzyme. Inhibition of the COX isoenzyme activity and/or expression may be the basis of future generation of anti-inflammatory and antineoplastic drugs. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：551 / 557

页数：7

共 43 条

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