Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation

被引:306
作者
Suarez, F
Lortholary, O
Hermine, O
Lecuit, M [1 ]
机构
[1] Univ Paris 05, Hop Necker Enfants Malad, Sch Med, Dept Infect Dis, F-75743 Paris 15, France
[2] Univ Paris 05, Hop Necker Enfants Malad, Sch Med, Dept Hematol,AP HP, F-75743 Paris 15, France
[3] Inst Pasteur, CNRS, FRE 2849, Mol Mycol Unit, Paris, France
[4] Inst Pasteur, INSERM, U604, Avenir Grp U604, Paris, France
[5] Univ Paris 05, Sch Med, CNRS, UMR 8603,IFR 94, F-75270 Paris, France
关键词
D O I
10.1182/blood-2005-09-3679
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Non-Hodgkin lymphomas develop from nodal and extranodal lymphoid tissues. A distinct subset of extranodal lymphomas arising from B cells of the marginal zone (MZ) of mucosa-associated lymphoid tissue (MALT) or spleen has been individualized. Growing evidence indicates that MZ lymphomas are associated with chronic antigenic stimulation by microbial pathogens and/or autoantigens. The list of microbial species associated with MZ lymphoproliferations has grown longer with molecular investigations and now comprises at least 5 distinct members: H pylori, C jejuni, B burgdorferi, C psittaci, and hepatitis C virus (HCV), which have been associated with gastric lymphoma, immunoproliferative small intestinal disease, cutaneous lymphoma, ocular lymphoma, and spleen lymphoma, respectively. A pathophysiologic scenario involving chronic and sustained stimulation of the immune system leading to lymphoid transformation has emerged. It defines a distinct category of infection-associated lymphoid malignancies, in which the infectious agent does not directly infect and transform lymphoid cells, as do the lymphotropic oncogenic viruses Epstein-Barr virus (EBV), human herpesvirus 8 (HHV8), and human T-lymphotropic virus 1 (HTLV-1), but rather indirectly increases the probability of lymphoid transformation by chronically stimulating the immune system to maintain a protracted proliferative state.
引用
收藏
页码:3034 / 3044
页数:11
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