New therapeutic approaches for adult T-cell leukaemia

被引:100
作者
Bazarbachi, A
Ghez, D
Lepelletier, Y
Nasr, R
de Thé, H
El-Sabban, ME
Hermine, O
机构
[1] Amer Univ Beirut, Dept Internal Med, Beirut, Lebanon
[2] Amer Univ Beirut, Dept Human Morphol, Beirut, Lebanon
[3] Hop Necker Enfants Malad, Dept Hematol, Paris, France
[4] Hop Necker Enfants Malad, CNRS, UMR 8147, Paris, France
[5] Hop St Louis, CNRS, UPR 9051, Paris, France
关键词
D O I
10.1016/S1470-2045(04)01608-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Adult T-cell leukaemia or lymphoma is an aggressive malignant disease of mature activated T cells caused by human T-cell lymphotropic virus type I. Patients with this disease have a very poor outlook because of intrinsic chemoresistance and severe immunosuppression. In acute adult T-cell leukaemia, clinical trials in Japan show that although non-targeted combinations of chemotherapy improve response, they do not have a significant effect on complete remission and survival. Antiretroviral therapy with combination zidovudine and interferon alfa, which induces a high rate of complete remission and lengthens survival, should be the first treatment option in acute adult T-cell leukaemia. Patients with adult T-cell lymphoma might benefit from initial aggressive chemotherapy followed by antiretroviral therapy. To prevent relapse in all patients allogeneic bone-marrow transplantation when feasible, or additional targeted therapy, should be mandatory. Based on current pathophysiology, we discuss promising new drugs such as arsenic trioxide, proteasome inhibitors, retinoids, and angiogenesis inhibitors, as well as cellular immunotherapy.
引用
收藏
页码:664 / 672
页数:9
相关论文
共 76 条
  • [1] Loss of the ex vivo but not the reinducible CD8+ T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia/lymphoma
    Arnulf, B
    Thorel, M
    Poirot, Y
    Tamouza, R
    Boulanger, E
    Jaccard, A
    Oksenhendler, E
    Hermine, O
    Pique, C
    [J]. LEUKEMIA, 2004, 18 (01) : 126 - 132
  • [2] Human T-cell lymphotropic virus oncoprotein Tax represses TGF-β1 signaling in human T cells via c-Jun activation:: a potential mechanism of HTLV-I leukemogenesis
    Arnulf, B
    Villemain, A
    Nicot, C
    Mordelet, E
    Charneau, P
    Kersual, J
    Zermati, Y
    Mauviel, A
    Bazarbachi, A
    Hermine, O
    [J]. BLOOD, 2002, 100 (12) : 4129 - 4138
  • [3] Is human T-cell lymphotropic virus type I really silent?
    Asquith, B
    Hanon, E
    Taylor, GP
    Bangham, CRM
    [J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 2000, 355 (1400) : 1013 - 1019
  • [4] Azimi N, 1999, J IMMUNOL, V163, P4064
  • [5] Arsenic trioxide and interferon-α synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells
    Bazarbachi, A
    El-Sabban, ME
    Nasr, R
    Quignon, F
    Awaraji, C
    Kersual, J
    Dianoux, L
    Zermati, Y
    Haidar, JH
    Hermine, O
    de Thé, H
    [J]. BLOOD, 1999, 93 (01) : 278 - 283
  • [6] Human T-cell lymphotropic virus type I-infected cells extravasate through the endothelial barrier by a local angiogenesis-like mechanism
    Bazarbachi, A
    Merhi, RA
    Gessain, A
    Talhouk, R
    El-Khoury, H
    Nasr, R
    Gout, O
    Sulahian, R
    Homaidan, F
    de Thé, H
    Hermine, O
    El-Sabban, ME
    [J]. CANCER RESEARCH, 2004, 64 (06) : 2039 - 2046
  • [7] Treatment with a combination of zidovudine and alpha-interferon in naive and pretreated adult T-cell leukemia/lymphoma patients
    Bazarbachi, A
    Hermine, O
    [J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1996, 13 : S186 - S190
  • [8] Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma
    Bazarbachi, A
    Nasr, R
    El-Sabban, ME
    Mahé, A
    Mahieux, R
    Gessain, A
    Darwiche, N
    Dbaibo, G
    Kersual, J
    Zermati, Y
    Dianoux, L
    Chelbi-Alix, MK
    de Thé, H
    Hermine, O
    [J]. LEUKEMIA, 2000, 14 (04) : 716 - 721
  • [9] Treatment of adult T-cell leukaemia/lymphoma: current strategy and future perspectives
    Bazarbachi, A
    Hermine, O
    [J]. VIRUS RESEARCH, 2001, 78 (1-2) : 79 - 92
  • [10] Treatment of adult T-cell leukemia-lymphoma by CHOP followed by therapy with antinucleosides, alpha interferon and oral etoposide
    Besson, C
    Panelatti, G
    Delaunay, C
    Gonin, C
    Brebion, A
    Hermine, O
    Plumelle, Y
    [J]. LEUKEMIA & LYMPHOMA, 2002, 43 (12) : 2275 - 2279