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Loss of the ex vivo but not the reinducible CD8+ T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia/lymphoma
被引:55
作者:

Arnulf, B
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机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France

Thorel, M
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h-index: 0
机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France

Poirot, Y
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h-index: 0
机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France

Tamouza, R
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h-index: 0
机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France

Boulanger, E
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h-index: 0
机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France

Jaccard, A
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h-index: 0
机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France

Oksenhendler, E
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机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France

Hermine, O
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机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France

Pique, C
论文数: 0 引用数: 0
h-index: 0
机构: Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France
机构:
[1] Hop St Louis, Inst Univ Hematol, CNRS, UPR 9051, F-75010 Paris, France
[2] Hop Necker Enfants Malad, Serv Hematol, Paris, France
[3] Hop Necker Enfants Malad, CNRS, UMR 8603, Paris, France
[4] Hop St Louis, Lab Immunol & Histocompatibil, Paris, France
[5] Hop St Louis, INSERM, U396, Paris, France
[6] Hop St Louis, Dept Immunohematol Clin, Paris, France
[7] Ctr Hosp Univ Limoges, Serv Hematol Clin, F-87042 Limoges, France
来源:
关键词:
retrovirus;
leukemia;
CTL;
D O I:
10.1038/sj.leu.2403176
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy (HAM). In asymptomatic carriers and HAM patients, HTLV-1 infection leads to a vigorous cytotoxic T-cell (CTL) response mainly directed to the regulatory Tax protein. In contrast, initial studies showed that anti-HTLV-1 CTL activities were not reproductively detected in ATLL patients, neither ex vivo, nor after in vitro restimulation. To better understand this discrepancy, we explored the anti-HTLV-1 CD8+ T-cell response of eight ATLL patients by using in vitro restimulated or freshly isolated CD8+ T cells. In all the ATLL patients, we found that mitogenic activation allowed the induction of CD8+ T cells able to lyse autologous HTLV-1-infected cells and/or to produce IFNgamma in response to Tax peptides. In contrast, only a minority of the patients possessed CD8+ cells able to respond ex vivo to the same epitopes. These findings indicate that although a restimulatable anti-HTLV-1 CTL activity persists during ATLL, the specific ex vivo response is not constantly maintained. This provides definitive evidence that the CD8+ T-cell response to HTLV-1 is affected by ATLL development and reveals that a major defect concerns the generation and/or the functionality of CD8+ effectors.
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页码:126 / 132
页数:7
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- [1] High activated and memory cytotoxic T-cell responses to HTLV-1 in healthy carriers and patients with tropical spastic paraparesis[J]. VIROLOGY, 1996, 217 (01) : 139 - 146Daenke, S论文数: 0 引用数: 0 h-index: 0机构: SIR CHARLES GARDNER HOSP,DEPT NEUROL & CLIN NEUROPHYSIOL,PERTH,WA 6009,AUSTRALIAKermode, AG论文数: 0 引用数: 0 h-index: 0机构: SIR CHARLES GARDNER HOSP,DEPT NEUROL & CLIN NEUROPHYSIOL,PERTH,WA 6009,AUSTRALIAHall, SE论文数: 0 引用数: 0 h-index: 0机构: SIR CHARLES GARDNER HOSP,DEPT NEUROL & CLIN NEUROPHYSIOL,PERTH,WA 6009,AUSTRALIATaylor, G论文数: 0 引用数: 0 h-index: 0机构: SIR CHARLES GARDNER HOSP,DEPT NEUROL & CLIN NEUROPHYSIOL,PERTH,WA 6009,AUSTRALIAWeber, J论文数: 0 引用数: 0 h-index: 0机构: SIR CHARLES GARDNER HOSP,DEPT NEUROL & CLIN NEUROPHYSIOL,PERTH,WA 6009,AUSTRALIANightingale, S论文数: 0 引用数: 0 h-index: 0机构: SIR CHARLES GARDNER HOSP,DEPT NEUROL & CLIN NEUROPHYSIOL,PERTH,WA 6009,AUSTRALIABangham, CRM论文数: 0 引用数: 0 h-index: 0机构: SIR CHARLES GARDNER HOSP,DEPT NEUROL & CLIN NEUROPHYSIOL,PERTH,WA 6009,AUSTRALIA
- [2] Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells[J]. BLOOD, 2002, 99 (09) : 3383 - 3389El-Sabban, ME论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, LebanonAbou Merhi, R论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, LebanonAbi Haidar, H论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, LebanonArnulf, B论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, LebanonKhoury, H论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, LebanonBasbous, J论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, LebanonNijmeh, J论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, Lebanonde Thé, H论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, LebanonHermine, O论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, LebanonBazarbachi, A论文数: 0 引用数: 0 h-index: 0机构: Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, Lebanon
- [3] HIGH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 (HTLV-1) SPECIFIC PRECURSOR CYTOTOXIC T-LYMPHOCYTE FREQUENCIES IN PATIENTS WITH HTLV-1 ASSOCIATED NEUROLOGICAL DISEASE[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) : 1567 - 1573ELOVAARA, I论文数: 0 引用数: 0 h-index: 0机构: MEDIMMUNE INC,GAITHERSBURG,MD 20878 MEDIMMUNE INC,GAITHERSBURG,MD 20878KOENIG, S论文数: 0 引用数: 0 h-index: 0机构: MEDIMMUNE INC,GAITHERSBURG,MD 20878 MEDIMMUNE INC,GAITHERSBURG,MD 20878BREWAH, AY论文数: 0 引用数: 0 h-index: 0机构: MEDIMMUNE INC,GAITHERSBURG,MD 20878 MEDIMMUNE INC,GAITHERSBURG,MD 20878WOODS, RM论文数: 0 引用数: 0 h-index: 0机构: MEDIMMUNE INC,GAITHERSBURG,MD 20878 MEDIMMUNE INC,GAITHERSBURG,MD 20878LEHKY, T论文数: 0 引用数: 0 h-index: 0机构: MEDIMMUNE INC,GAITHERSBURG,MD 20878 MEDIMMUNE INC,GAITHERSBURG,MD 20878JACOBSON, S论文数: 0 引用数: 0 h-index: 0机构: MEDIMMUNE INC,GAITHERSBURG,MD 20878 MEDIMMUNE INC,GAITHERSBURG,MD 20878
- [4] Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia[J]. BLOOD, 2001, 97 (04) : 987 - 993Furukawa, Y论文数: 0 引用数: 0 h-index: 0机构: Kagoshima Univ, Fac Med, Dept Internal Med 3, Kagoshima 8908520, JapanKubota, R论文数: 0 引用数: 0 h-index: 0机构: Kagoshima Univ, Fac Med, Dept Internal Med 3, Kagoshima 8908520, JapanTara, M论文数: 0 引用数: 0 h-index: 0机构: Kagoshima Univ, Fac Med, Dept Internal Med 3, Kagoshima 8908520, JapanIzumo, S论文数: 0 引用数: 0 h-index: 0机构: Kagoshima Univ, Fac Med, Dept Internal Med 3, Kagoshima 8908520, JapanOsame, M论文数: 0 引用数: 0 h-index: 0机构: Kagoshima Univ, Fac Med, Dept Internal Med 3, Kagoshima 8908520, Japan
- [5] RAPID DEVELOPMENT OF MYELOPATHY AFTER HTLV-I INFECTION ACQUIRED BY TRANSFUSION DURING CARDIAC TRANSPLANTATION[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (06) : 383 - 388GOUT, O论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCEBAULAC, M论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCEGESSAIN, A论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCESEMAH, F论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCESAAL, F论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCEPERIES, J论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCECABROL, C论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCEFOUCAULTFRETZ, C论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCELAPLANE, D论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCESIGAUX, F论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCEDETHE, G论文数: 0 引用数: 0 h-index: 0机构: HOP LA PITIE SALPETRIERE,SERV CHIRURG CARDIA & VASC,F-75651 PARIS 13,FRANCE
- [6] Regression of human T-cell leukemia virus type I (HTLV-I)-associated lymphomas in a rat model: Peptide-induced T-cell immunity[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (23) : 1775 - 1783Hanabuchi, S论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, JapanOhashi, T论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, JapanKoya, Y论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, JapanKato, H论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, JapanHasegawa, A论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, JapanTakemura, F论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, JapanMasuda, T论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, JapanKannagi, M论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 1138519, Japan
- [7] Fratricide among CD8+ T lymphocytes naturally infected with human T cell lymphotropic virus type I[J]. IMMUNITY, 2000, 13 (05) : 657 - 664Hanon, E论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandStinchcombe, JC论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandSaito, M论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandAsquith, BE论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandTaylor, GP论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandTanaka, Y论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandWeber, JN论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandGriffiths, GM论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandBangham, CRM论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, England
- [8] Abundant Tax protein expression in CD4+T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes[J]. BLOOD, 2000, 95 (04) : 1386 - 1392Hanon, E论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandHall, S论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandTaylor, GP论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandSaito, M论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandDavis, R论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandTanaka, Y论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandUsuku, K论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandOsame, M论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandWeber, JN论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, EnglandBangham, CRM论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol & Genitourinary Med & Communicable D, London W2 1PG, England
- [9] CIRCULATING CD8+ CYTOTOXIC LYMPHOCYTES-T SPECIFIC FOR HTLV-I PX IN PATIENTS WITH HTLV-I ASSOCIATED NEUROLOGICAL DISEASE[J]. NATURE, 1990, 348 (6298) : 245 - 248JACOBSON, S论文数: 0 引用数: 0 h-index: 0机构: NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892SHIDA, H论文数: 0 引用数: 0 h-index: 0机构: NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892MCFARLIN, DE论文数: 0 引用数: 0 h-index: 0机构: NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892FAUCI, AS论文数: 0 引用数: 0 h-index: 0机构: NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892KOENIG, S论文数: 0 引用数: 0 h-index: 0机构: NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892
- [10] HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) : 3848 - 3853Jeffery, KJM论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandUsuku, K论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandHall, SE论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandMatsumoto, W论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandTaylor, GP论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandProcter, J论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandBunce, M论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandOgg, GS论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandWelsh, KI论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandWeber, JN论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandLloyd, AL论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandNowak, MA论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandNagai, M论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandKodama, D论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandIzumo, S论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandOsame, M论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, EnglandBangham, CRM论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, England