Conditional alleles in mice: Practical considerations for tissue-specific knockouts

被引：111

作者：

Kwan, KM ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA

来源：

GENESIS | 2002年 / 32卷 / 02期

关键词：

conditional genetics; Cre-IoxP; Flp-FRT; tissue-specific knockout; mosaic;

D O I：

10.1002/gene.10068

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：49 / 62

页数：14

共 139 条

[51] Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
Jackson-Grusby, L
Beard, C
Possemato, R
Tudor, M
Fambrough, D
Csankovszki, G
Dausman, T
Lee, P
Wilson, C
Lander, E
Jaenisch, R
[J]. NATURE GENETICS, 2001, 27 (01) : 31 - 39
[52] Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase
Jo, DW
Nashabi, A
Doxsee, C
Lin, Q
Unutmaz, D
Chen, J
Ruley, HE
[J]. NATURE BIOTECHNOLOGY, 2001, 19 (10) : 929 - 933
[53] Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
Jonkers, J
Meuwissen, R
van der Gulden, H
Peterse, H
van der Valk, M
Berns, A
[J]. NATURE GENETICS, 2001, 29 (04) : 418 - 425
[54] Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo
Kaartinen, V
Nagy, A
[J]. GENESIS, 2001, 31 (03) : 126 - 129
[55] Inducible site-specific recombination in the brain
Kellendonk, C
Tronche, F
Casanova, E
Anlag, K
Opherk, C
Schütz, G
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (01) : 175 - 182
[56] Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
Kulkarni, RN
Brüning, JC
Winnay, JN
Postic, C
Magnuson, MA
Kahn, CR
[J]. CELL, 1999, 96 (03) : 329 - 339
[57] Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease
Kwon, CH
Zhu, XY
Zhang, JY
Knoop, LL
Tharp, R
Smeyne, RJ
Eberhart, CG
Burger, PC
Baker, SJ
[J]. NATURE GENETICS, 2001, 29 (04) : 404 - 411
[58] Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
Lakso, M
Pichel, JG
Gorman, JR
Sauer, B
Okamoto, Y
Lee, E
Alt, FW
Westphal, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) : 5860 - 5865
[59] TARGETED ONCOGENE ACTIVATION BY SITE-SPECIFIC RECOMBINATION IN TRANSGENIC MICE
LAKSO, M
SAUER, B
MOSINGER, B
LEE, EJ
MANNING, RW
YU, SH
MULDER, KL
WESTPHAL, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) : 6232 - 6236
[60] Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
Larsson, NG
Wang, JM
Wilhelmsson, H
Oldfors, A
Rustin, P
Lewandoski, M
Barsh, GS
Clayton, DA
[J]. NATURE GENETICS, 1998, 18 (03) : 231 - 236

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