Control of amyloid β-peptide protoribril formation by a designed template assembly

被引：41

作者：

Dolphin, GT ^{[1
]}

Dumy, P ^{[1
]}

Garcia, J ^{[1
]}

机构：

[1] Univ Grenoble 1, LEDSS, UMR 5616, ICMG FR, F-38041 Grenoble 9, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 17期

关键词：

amyloids; peptides; protein design; protein folding; template synthesis;

D O I：

10.1002/anie.200600395

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Insight into amyloids: Four identical segments of the amyloid β-peptide, which is associated with Alzheimer's disease by fibril formation, were successfully attached to a cyclic decapeptide template. The assembly forms soluble protofibrils (see picture) that reveal a cross-β-sheet structure, with fast controllable kinetics and without a lag phase. (Figure Presented) © 2006 Wiley-VCH Verlag GmbH £Co. KGaA.

引用

页码：2699 / 2702

页数：4

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