A CONVENIENT SYNTHESIS OF CYCLIC-PEPTIDES AS REGIOSELECTIVELY ADDRESSABLE FUNCTIONALIZED TEMPLATES (RAFT)

被引：117

作者：

DUMY, P

EGGLESTON, IM

CERVIGNI, S

SILA, U

SUN, X

MUTTER, M

机构：

[1] Institute of Organic Chemistry, University of Lausanne, CH-1015 Lausanne, BCH-Dorigny

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 08期

关键词：

D O I：

10.1016/0040-4039(94)02481-P

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclic decapeptides containing up to four orthogonally protected lysine residues have been efficiently prepared by a combined solid phase and solution strategy. These cyclic peptides represent new Regioselectively Addressable Functionalized Templates (RAFT), which are suitable for use in protein de novo design according to the TASP concept.

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页码：1255 / 1258

页数：4

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