Inhibition of 4-nitroquinoline-1-oxide genotoxicity by Bacillus strains

被引：18

作者：

Caldini, G ^{[1
]}

Trotta, F ^{[1
]}

Cenci, G ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Biol Cellulare & Mol, I-06126 Perugia, Italy

来源：

RESEARCH IN MICROBIOLOGY | 2002年 / 153卷 / 03期

关键词：

bacillus; probiotics; 4-nitroquinoline-1-oxide; genotoxicity tests; SOS-chromotest;

D O I：

10.1016/S0923-2508(02)01302-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effect of 16 Bacillus strains from pharmaceutical probiotic preparations (Bacillus spp.) and collection (B. subtilis, B. firmus, B. megaterium, B. pumilus) on genotoxicity induced by the known mutagen 4-nitroquinoline-1-oxide (4-NQO) was studied using the short-term bacterial assay SOS-chromotest, with Escherichia coli PQ37 as the tester organism. It was found that the activity of 0.1 mM 4-NQO was reduced (P < 0.01) after coincubation with Bacillus suspensions (10(8) CFU/ml for 150 min at 37 degreesC). All isolates showed potential for deactivating 4-NQO, and genotoxicity inhibition ranged from 92.9 to 100%. There were no appreciable differences in behaviour observed among probiotic and collection strains or in relation to species. The observed antigenotoxicity was associated with a clear-cut modification of 4-NQO molecular characteristics. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：165 / 171

页数：7

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