Neonatal hyperinsulinism

被引：30

作者：

Glaser, B ^{[1
]}

Landau, H

Permutt, MA

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Endocrinol & Metab, Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Pediat, Jerusalem, Israel

[3] Washington Univ, Sch Med, Div Endocrinol Diabet & Metab, St Louis, MO 63110 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1043-2760(98)00102-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypoglycemia as a result of hyperinsulinism in the newborn (HI) is a clinically heterogeneous entity that presents a diagnostic and therapeutic challenge to the treating physician. Recent discoveries have shown that mutations in four different beta-cell genes cause HI. However, for many HI patients, the molecular etiology is unknown, and other genes might be involved. The study of the molecular biology of HI has Zed to a better understanding of pancreatic beta-cell physiology. In the future, this might result in the development of novel drugs for the treatment of both hyperinsulinism and non-insulin-dependent diabetes.

引用

页码：55 / 61

页数：7

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