Polymeric gadolinium chelate magnetic resonance imaging contrast agents: Design, synthesis, and properties

被引：65

作者：

Ladd, DL ^{[1
]}

Hollister, R ^{[1
]}

Peng, X ^{[1
]}

Wei, D ^{[1
]}

Wu, G ^{[1
]}

Delecki, D ^{[1
]}

Snow, RA ^{[1
]}

Toner, JL ^{[1
]}

Kellar, K ^{[1
]}

Eck, J ^{[1
]}

Desai, VC ^{[1
]}

Raymond, G ^{[1
]}

Kinter, LB ^{[1
]}

Desser, TS ^{[1
]}

Rubin, DL ^{[1
]}

机构：

[1] Nycomed Amersham Imaging, Torsten Almen Res Ctr, Wayne, PA 19087 USA

来源：

BIOCONJUGATE CHEMISTRY | 1999年 / 10卷 / 03期

关键词：

D O I：

10.1021/bc980086+

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interest as potential MRI blood pool contrast agents. The polymers were designed so that important physical properties including molecular weight, relaxivity, metal content, viscosity, and chelate stability could be varied. We have shown that, by selecting polymers of the appropriate MW, extended blood pool retention can be achieved. In addition, relaxivity can be manipulated by changing the polymer rigidity, metal content affected by monomer selection, viscosity by polymer shape, and chelate stability by chelator selection.

引用

页码：361 / 370

页数：10

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